Chronic kidney disease (CKD) is a pathological process with various etiologies, causing a progressive and irreversible decline in kidney function. Hemodialysis is used to remove certain metabolic waste or toxins. The purpose of this study was to analyze the relationship between hemoglobin levels, erythrocyte count, and creatinine levels in chronic kidneys after undergoing hemodialysis. The research design used was Cross Sectional with an analytical observational method. In this study, there were 25 respondents who were taken using the Purposive Sampling technique. The data analysis used was the normalization test using the Pearson Test. Based on the Pearson Correlation test between Hemoglobin Levels, Erythrocyte Counts, and Creatinine Levels in patients with chronic kidney disease after undergoing hemodialysis,  the results  were obtained with a correlation coefficient value of 0.932 which means that the correlation strength is very strong. As for the sig value. 0.000 (<0.05) there was an association between Hemoglobin Level and Erythrocyte Number in patients with chronic kidney disease. The value of the correlation coefficient is 0.099 As for the value of sig. 0.636 (>0.05) indicates that there is no association between Hemoglobin Levels and Creatinine Levels in patients with chronic kidney disease. The conclusion was that there was a relationship between Hemoglobin levels and Erythrocyte Count in patients with chronic kidney disease at Gambiran Hospital, but there was no relationship between Hemoglobin levels and Creatinine levels in patients with chronic kidney disease in patients with chronic kidney disease and there was no association between the number of erythrocytes and creatinine levels in patients with chronic kidney disease at Gambiran Hospital