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Khoirun Mukhsinin Putra
Yulianto Kusnadi
Ratna Maila Dewi
Alwi Shahab

Type 2 diabetes mellitus (T2DM) is strongly associated with an increasing risk of cardiovascular complications and is often paired with atherogenic dyslipidemia. Remnant cholesterol (RC) and non-high-density lipoprotein (non-HDL) cholesterol are increasingly recognized as markers reflecting the entire burden of atherogenic lipoproteins. Nevertheless, how these parameters relate to each other and to glycemic control remains insufficiently explored. This was a cross-sectional research designed to assess the correlation between RC and non-HDL cholesterol, along with their association with glycemic status in patients with T2DM. A cross-sectional study was conducted using secondary clinical data obtained from medical records of patients attending the Integrated Diabetes Clinic of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, between November and December 2025. All participants were receiving statin therapy. Remnant cholesterol was calculated as total cholesterol minus LDL cholesterol minus HDL cholesterol, whereas non-HDL cholesterol was calculated as total cholesterol minus HDL cholesterol. Correlation analysis was performed using Spearman’s rank correlation coefficient because all variables showed non-normal distributions. A total of 100 participants were analyzed. The results showed a moderate positive correlation between remnant cholesterol and non-HDL cholesterol (r = 0.618; p < 0.001). Conversely, no statistically significant correlation was identified between HbA1c and non-HDL cholesterol (r = –0.180; p = 0.074). These findings indicate that remnant cholesterol was positively correlated with non-HDL cholesterol, whereas HbA1c was not. Because RC and non-HDL cholesterol share calculated lipid components and all participants were receiving statin therapy, these findings should be interpreted cautiously.

Keywords: HbA1c Atherogenic Dyslipidemia Type 2 Diabetes Mellitus Non-HDL Cholesterol Remnant Cholesterol