Antimicrobial agents, both topical and systemic, are commonly used in dermatology for the management of infectious skin diseases. Data regarding antimicrobial prescribing patterns in dermatovenereology outpatient settings in Indonesia remain limited. This study aimed to describe the antimicrobial prescribing profile at the Dermatovenereology Outpatient Clinic of Universitas Sebelas Maret Hospital, Surakarta. A retrospective descriptive study was conducted using electronic medical records and outpatient pharmacy data. Prescriptions containing antimicrobial agents issued at the Dermatovenereology Outpatient Clinic of Universitas Sebelas Maret Hospital between August and December 2024 were analyzed. Of 2,383 dermatovenereology outpatients, 510 (21.4%) received an antimicrobial agent. Topical antimicrobials were prescribed more frequently than systemic antimicrobials. The most commonly prescribed topical antimicrobials were 2% mupirocin cream (42.94%), 0.1% gentamicin cream (23.14%), and 2% fusidic acid cream (7.06%). Among systemic antimicrobials, azithromycin was the most frequently prescribed (13.3%), followed by cefixime (5.69%), metronidazole (2.75%), clindamycin (1.96%), doxycycline (1.76%), and cefadroxil (1.37%). Antimicrobial prescribing at the Dermatovenereology Outpatient Clinic of Universitas Sebelas Maret Hospital was dominated by topical antimicrobial agents, particularly 2% mupirocin cream and 0.1% gentamicin cream, while azithromycin was the most frequently prescribed systemic antimicrobial. These findings provide baseline data for monitoring antimicrobial use and may support antimicrobial stewardship initiatives in dermatology practice.