Chronic kidney disease (CKD) is a growing global health problem that often requires renal replacement therapy in the form of hemodialysis. Electrolyte imbalances, particularly abnormalities in sodium, potassium, and chloride levels, are commonly found in patients with CKD and can lead to serious complications. The frequency of hemodialysis is considered an important factor in maintaining electrolyte balance; however, previous studies have reported inconsistent findings. This study is an analytical observational study with a cross-sectional design. Data were collected from the medical records of CKD patients undergoing routine hemodialysis at Bakti Timah Hospital, Pangkalpinang, between September 2025 and February 2026. A total of 55 subjects were selected using a consecutive sampling technique based on the inclusion and exclusion criteria. The independent variable was hemodialysis frequency, while the dependent variables were serum sodium, potassium, and chloride levels. Data were analyzed using Spearman's correlation test with a significance level of p<0.05. The median hemodialysis frequency over six months was 47 sessions. The median serum sodium, potassium, and chloride levels were 138 mmol/L, 4.6 mmol/L, and 105 mmol/L, respectively. Statistical analysis showed no significant correlation between hemodialysis frequency and sodium levels (r=-0.131; p=0.341), potassium levels (r=0.080; p=0.561), or chloride levels (r=-0.113; p=0.411). Hemodialysis frequency was not significantly associated with serum sodium, potassium, or chloride levels in patients with chronic kidney disease undergoing routine hemodialysis.