Breast cancer is a malignancy which invaded breast tissue in the form of ductal or lobular. One most therapy
which is given is neoadjuvant chemotherapy. Neoadjuvant Chemotherapy can reduce tumor size so that surgery
can be performed with good breast removal with Modification of Radical Mastectomy (MRM) and Breast
Conservative Therapy (BCT). This purpose from this research is to find out neoadjuvant chemotherapy response in
Locally Advanced Breast Cancer Patients which has received chemotherapy treatment in RSUP dr Mohammad
Hoesin Palembang. This observational descriptive study was conducted at RSUP Mohammad Hoesin Palembang in
the period between October until November 2019. The sample of this study was locally advanced breast Cancer
patients who underwent chemotherapy that met the inclusion and exclusion criteria. The data were obtained by
interviews and observed medical records from the patients which were then analyzed by univariate analysis using
SPSS version 25. In this study there were 34 locally advanced breast cancer patients who fulfilled the inclusion and
exclusion criteria. 24 of 34 patients (70,6%) received positive response and 10 of 34 patients (29,4%) received
negative response.